Novel Benzosuberone Derivatives: Synthesis, Characterization and Antibacterial Activity

The synthesis of novel amide derivatives of benzosuberone 7a-j from commercially available benzosuberone was successfully achieved in six steps. Some of the important reactions that are involved in the synthesis are (i) insertion of methylester (ii) Suzki reaction and (iii) saponification followed by amide bond formation. The newly synthesis benzosuberone derivatives 7a-j were screened for antibacterial activity and the results indicated that in general, benzosuberone derivatives with R = piperazine ring showed good antibacterial activity.